Experimental · Computational
Network Dynamics of Affective Task Switching
Exploration of thalamo-cortical activity during an affective task-switching paradigm in patients with intracranial electrodes.
// hello, world
Computational & Systems Neuroscientist
Network dynamics · Neuromodulation · Biomedical engineering
[ 01 — ABOUT ]
I am a neuroscientist working at the intersection of computation and experiment, with a focus on network- and systems-level brain disorders. My background in computer science informs how I approach experimental design, data analysis, and instrumentation — from large-scale, intracranial neural recordings to neuromodulation for causal analysis and therapeutic interventions.
My work has spanned electrophysiology, behavioral analysis, and the design and fabrication of biomedical devices. I am interested in how brain-wide interactions give rise to epilepsy and psychiatric disorders, and how perturbations to networks can restore healthy function.
Outside the lab I contribute to open-source tools, foster animals, and enjoy working on a variety of creative and technical projects.
[ 02 — SKILLS ]
// Computational
// Experimental
// Engineering
[ 03 — PROJECTS ]
Experimental · Computational
Exploration of thalamo-cortical activity during an affective task-switching paradigm in patients with intracranial electrodes.
Computational
Analysis of thalamo-cortical interactions during seizures in patients with intracranial electrodes, and development of a computational model to explain observed dynamics.
Experimental · Engineering
Testing unique combinations of ultrasound and electrical stimulation on neuronal cell cultures using a custom-built experimental rig.
[ 04 — PUBLICATIONS ]
// Preprints & In Review
Nester, E., et al. (2026). Thalamocortical network dynamics in focal epilepsy: SEEG investigation. bioRxiv
// Thesis
Nester, E. (2022). Remote Modulation of Neural Computation in Cell Cultures Using Electric Field and Ultrasound Combinations. [Master's of Science, Arizona State University]. ProQuest Dissertations & Theses.
// Journal Articles
Behrens, H. W., ..., Nester, E., et al. (2018). Datastorm-FE: A data- and decision-flow and coordination engine for coupled simulation ensembles. Proceedings VLDB Endowment, 11 (12), 1781-1794.
// Conference Presentations
Nester, E., et al. (2026). Aperiodic slope may be a local physiologic biomarker for thalamic neuromodulation in epilepsy. NYC Neuromodulation, New York, New York.
Nester, E., et al. (2025). Intracranial Electrophysiologic Biomarkers of the Ictal Thalamocortical Network in Drug-Resistant Epilepsy. Neural Interfaces, Arlington, Virginia.
Nester, E., et al. (2024). Parallel Changes in Aperiodic Slope Across the Thalamo-cortical Ictal Network. AES Annual Meeting, Los Angeles, California.